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J Biol Chem. 2000 Apr 14;275(15):11300-5.

Biosynthesis of vitamin B(6) in rhizobium.

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1
Department of Applied Microbiology, Nippon Roche Research Center, Kamakura, Kanagawa 247-8530, Japan. masaaki.tazoe@roche.com

Abstract

The biosynthetic pathway of pyridoxol (vitamin B(6)) in Rhizobium was clarified by studies on the incorporation of (13)C- or (15)N-labeled precursors into pyridoxol or its biosynthetic intermediates. Pyridoxol was formed by ring closure of two compounds, 1-deoxy-D-xylulose and 4-hydroxy-L-threonine. The former was formed from D-glyceraldehyde and pyruvate through decarboxylation of pyruvate, and the latter from glycine and glycolaldehyde.

PMID:
10753941
[Indexed for MEDLINE]
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