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Curr Opin Struct Biol. 2000 Apr;10(2):242-50.

Dis-assembly lines: the proteasome and related ATPase-assisted proteases.

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Department of Molecular Structural Biology, Max-Planck-Institut für Biochemie, Martinsried, 82152, Germany.


Self-compartmentalizing proteases, such as the proteasome and several prokaryotic energy-dependent proteases, are designed to act in the crowded environment of the cell. Proteins destined for degradation are recognized and unfolded by regulatory subcomplexes that invariably contain ATPase modules, before being translocated into another subcomplex, the proteolytic core, for degradation. The sequential actions effected on substrates are reflected in the linear arrangement of these subcomplexes; thus, the holocomplexes are organized as molecular disassembly and degradation lines.

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