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Curr Opin Struct Biol. 2000 Apr;10(2):220-8.

Clathrin coat construction in endocytosis.

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  • 1Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK.


Electron cryomicroscopy of the clathrin coat and X-ray crystallography of parts of the clathrin heavy chain combine to give a detailed picture of the clathrin molecule, assembled as a cage. Recently determined domain structures of other components of the endocytic machinery, particularly the mu2 subunit and the alpha-appendage domain of the AP2 adaptor complex, provide important information on the sequence of recognition events involved in the dynamic process of clathrin coat assembly.

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