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Curr Opin Genet Dev. 2000 Apr;10(2):199-203.

Locus control regions and epigenetic chromatin modifiers.

Author information

1
Department of Medicine, Gene Control Mechanisms and Disease, Imperial College School of Medicine, Medical Research Council, Clinical Sciences Centre, Hammersmith Hospital, London, W12 ONN. r-festen@nimr.mrc.ac.uk

Abstract

Locus control regions are defined as gene regulatory sequences that enable chromosomal position-independent gene expression in transgenic mice. Recent studies have shown the ability of such regions to overcome the highly repressive effect of heterochromatin and have identified both trans-acting and cis-acting factors that participate in gene silencing and activation mechanisms.

PMID:
10753778
DOI:
10.1016/s0959-437x(00)00060-5
[Indexed for MEDLINE]

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