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Curr Opin Genet Dev. 2000 Apr;10(2):204-10.

The HP1 protein family: getting a grip on chromatin.

Author information

1
Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA. eissenjc@slu.edu

Abstract

HP1 was first described in Drosophila as a heterochromatin-associated protein with dosage-dependent effects on heterochromatin-induced gene silencing. Recently, membership of the HP1 protein family has expanded tremendously. A number of intriguing interactions between HP1 and other proteins have been described, implicating HP1 in gene regulation, DNA replication, and nuclear architecture.

PMID:
10753776
[Indexed for MEDLINE]

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