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Curr Opin Biotechnol. 2000 Apr;11(2):180-6.

Mathematical modelling of metabolism.

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Department of Chemical Engineering, CP 61548, University of São Paulo, São Paulo, 05424-970, Brazil.


Mathematical models of the cellular metabolism have a special interest within biotechnology. Many different kinds of commercially important products are derived from the cell factory, and metabolic engineering can be applied to improve existing production processes, as well as to make new processes available. Both stoichiometric and kinetic models have been used to investigate the metabolism, which has resulted in defining the optimal fermentation conditions, as well as in directing the genetic changes to be introduced in order to obtain a good producer strain or cell line. With the increasing availability of genomic information and powerful analytical techniques, mathematical models also serve as a tool for understanding the cellular metabolism and physiology.

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