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Virology. 2000 Apr 10;269(2):370-6.

Polyomavirus large T antigen mutants affected in viral DNA replication.

Author information

1
Department of Biochemistry, Université de Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada.

Abstract

We have characterized two polyomavirus large T antigen mutants with different properties in viral DNA replication. dl-97, a mutant active in immortalization, exerts a dominant negative effect in viral DNA replication. 13val, which is defective in both immortalization and viral DNA replication, has a lesion in the putative DnaJ domain affecting the block of Rb function.

PMID:
10753715
DOI:
10.1006/viro.2000.0231
[Indexed for MEDLINE]
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