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Growth Horm IGF Res. 2000 Feb;10(1):53-9.

Diabetic retinopathy is associated with decreased serum levels of free IGF-I and changes of IGF-binding proteins.

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  • 1Department of Internal Medicine, University of Ulm, Germany.


In patients with diabetic retinopathy, elevated serum levels of total circulating insulin-like growth factor-I (IGF-I) have been implicated as an important mediator of the disease. There is no study, however, measuring free IGF-I levels in patients with diabetic retinopathy which mediate the biological effects of IGF-I and are modulated by a complex system of six specific IGF binding proteins (IGFBPs) and several IGFBP proteases.

Copyright 2000 Harcourt Publishers Ltd.

[PubMed - indexed for MEDLINE]
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