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Curr Opin Lipidol. 2000 Feb;11(1):3-7.

Omega-3 polyunsaturated fatty acid regulation of gene expression.

Author information

1
Division of Nutritional Sciences, and the Institute for Cellular and Molecular Biology, University of Texas at Austin, 78712-1097, USA. pprice@mail.utexas.edu

Abstract

This review describes the mechanisms by which polyunsaturated fatty acids regulate the activity of the nuclear transcription factors, peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1, and it describes the role that the peroxisome proliferator-activated receptor and sterol regulatory element binding protein-1 play in coordinating the regulation of lipid synthesis, lipid oxidation, and thermogenesis. Finally, the requirement for dietary polyunsaturated fatty acids, particularly n-3 fatty acids, is defined in terms of the effects polyunsaturated fatty acids exert on gene expression and the role that these effects play in overall energy balance.

PMID:
10750688
[Indexed for MEDLINE]

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