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Clin Nephrol. 2000 Mar;53(3):182-7.

A 10-year follow-up study of renal transplant recipients treated with cyclosporine. Japanese Cyclosporine Kidney Transplant Study Group.

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1
Ota Medical Institute, Tokyo, Japan.

Abstract

AIM:

In this report a 10-year follow-up of Japanese multicentre trial of renal transplantation using cyclosporine is described.

MATERIAL AND METHODS:

A total of 1,323 recipients, including 1,055 (79.7%) living donor (LD) transplantations and 268 (20. 3%) non-heart-beating cadaveric donor (CD) transplantations, were enrolled in the study.

RESULTS:

Favorable results; graft survival at 1, 5 and 10 years were 95.8%, 80.9%, 56.8%, respectively, for LD, and 88.7%, 74.2%, 58.8%, respectively, even for CD, were obtained. No serious adverse reactions or complications were observed in this group of patients excepting 28 cases (2.0%) of malignant tumors. There were no cases of abnormality in 49 babies delivered during the term.

CONCLUSION:

We demonstrate the interesting findings that graft survival of non-heart-beating CD are surprisingly as good as that of LD and the safety issues are almost equal to other available data in other countries.

PMID:
10749296
[Indexed for MEDLINE]
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