Format

Send to

Choose Destination
Curr Opin Microbiol. 2000 Apr;3(2):132-7.

The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more.

Author information

1
Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA. gartenbe@umdnj.edu

Abstract

The Sir2, Sir3, and Sir4 proteins of the yeast Saccharomyces cerevisiae elicit transcriptional silencing by forming repressive chromatin structures that are confined to specific chromosomal domains. Recent discoveries establish new and unexpected roles for the proteins in seemingly unrelated arenas of chromosome biology, including double-strand break repair, structure and function of the nucleolus, aging, cell cycle regulation, and checkpoint control.

PMID:
10744999
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center