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J Trauma. 2000 Mar;48(3):558-61.

Clinical measurement, statistical analysis, and risk-benefit: controversies from trials of spinal injury.

Author information

1
Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06520-8034, USA.

Abstract

BACKGROUND:

The National Acute Spinal Cord Injury Studies have been a series of trials assessing the role of pharmacologic agents in the prevention of secondary neuronal damage after acute spinal cord injury.

METHODS:

The trials were multicenter randomized, controlled studies.

RESULTS:

Two trials have demonstrated the efficacy of high-dose methylprednisolone in improving neurologic and functional recovery and have shown a reassuring safety profile.

CONCLUSION:

This study responds to a recent commentary on these trials and examines in particular the roles of clinical measurement, statistical analysis, and risk benefit in assembling evidence for or against innovative therapies.

PMID:
10744306
[Indexed for MEDLINE]

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