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Bioorg Med Chem Lett. 2000 Mar 6;10(5):509-12.

N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.

Author information

1
Exploratory Research 1, Drug Discovery Laboratories, Pharmaceutical Research Division, Yoshitomi Pharmaceutical Industries, Ltd., Iruma, Saitama, Japan. fujo@yoshitomi.co.jp

Abstract

A series of benzamides was synthesized as selective agonists for the 5-HT1A receptor. It was found that (S)-N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarb oxamide(7-(S)) has potent and selective agonistic activity for the 5-HT1A receptor (5-HT1A; Ki 0.49 nmol/L, D2; IC50 = >1000 nmol/L, 5-HT2; Ki = 240 nmol/L).

PMID:
10743959
DOI:
10.1016/s0960-894x(00)00030-5
[Indexed for MEDLINE]

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