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Bioorg Med Chem Lett. 2000 Mar 6;10(5):503-7.

Solid phase synthesis of diamides as potential bone resorption inhibitors.

Author information

1
Preclinical R&D, AstraZeneca R&D Mölndal, Sweden. karin.edvinsson@karobio.se

Abstract

Unsymmetrical diamide libraries have been prepared by a general and versatile solid phase route, using diacid templates in combination with aromatic and aliphatic amines chosen with the help of statistical experimental design. The compounds were tested as potential inhibitors of osteoclast vacuolar ATPase.

PMID:
10743958
[Indexed for MEDLINE]

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