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Bioorg Med Chem Lett. 2000 Mar 6;10(5):465-8.

(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.

Author information

1
Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy. viola@ruflo.chimfarm.unipg.it

Abstract

A series of compounds having a piperazine moiety variously linked to the benzothiazine nucleus were synthesized and evaluated for their in vitro alpha-adrenoceptor affinity by radioligand receptor binding assays. Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good alpha1-adrenoreceptor ligands.

PMID:
10743949
[Indexed for MEDLINE]

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