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Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.

Author information

1
College of Pharmacy, Ewha Womans University, Seoul, South Korea. ckryu@mm.ewha.ac.kr

Abstract

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines.

PMID:
10743948
DOI:
10.1016/s0960-894x(00)00014-7
[Indexed for MEDLINE]

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