Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2000 Mar 6;10(5):453-5.

Synthesis of neurotensin(9-13) analogues exhibiting enhanced human neurotensin receptor binding affinities.

Author information

1
Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425-2303, USA.

Abstract

Recent evidence is consistent with neurotensin (NT)(8-13) adopting a Type I beta-turn conformation while binding the NT receptor, which would place the cationic side-chains of Arg(8) and Arg(9) in close proximity. This was the basis for the design, synthesis and analysis of truncated NT(9-13) analogues 1-5 with dicationic position 9 side-chains to emulate the functions of the 8 and 9 side-chains of NT(8-13).

PMID:
10743946
DOI:
10.1016/s0960-894x(00)00018-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center