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Bioorg Med Chem Lett. 2000 Mar 6;10(5):411-4.

Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6-g]quin olines.

Author information

1
Department of Medicinal Chemistry, Ligand Pharmaceuticals, San Diego, CA 92121, USA.

Abstract

A series of nonsteroidal human androgen receptor (hAR) antagonists based on 8-substituted 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethylpyrido[3,2-g]quin olines was synthesized. Compounds in this series were tested for the ability to bind to hAR and inhibit hAR-dependent transcription in a mammalian cellular background.

PMID:
10743937
DOI:
10.1016/s0960-894x(00)00010-x
[Indexed for MEDLINE]

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