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J Affect Disord. 1998 Nov;51(2):153-64.

Are childhood psychiatric histories of bipolar adolescents associated with family history, psychosis, and response to lithium treatment?

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  • 1Division of Child and Adolescent Psychiatry, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.

Abstract

OBJECTIVE:

To examine if childhood psychiatric diagnoses are associated with family history, psychosis, age, and lithium response.

METHOD:

Associations among variables, and their contributions to explaining lithium response were examined in 48 bipolar adolescents enrolled in a study of lithium.

RESULTS:

Presence of a childhood diagnosis was not associated with family psychiatric history or lithium response. Subjects with psychotic features, however, were less likely to have a childhood psychiatric diagnosis, were older, and had a poorer response rate to lithium than subjects without psychosis.

DISCUSSION:

Heterogeneity within bipolar adolescents may be based on clinical features such as psychosis rather than childhood or family history alone.

PMID:
10743848
[PubMed - indexed for MEDLINE]
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