Format

Send to

Choose Destination
Zhonghua Zhong Liu Za Zhi. 1997 Jan;19(1):53-5.

[Effects of icariin on the differentiation of HL-60 cells].

[Article in Chinese]

Author information

1
Shandong Provincial Qianfoshan Hospital, Jinan.

Abstract

OBJECTIVE:

In order to search for new tumor differentiation inducer, the effects and mechanism of Icariin were studied.

METHODS:

Icariin is an monomer purified from Epimedium Koreanum Nakai. The differentiation of induction effects of Icariin were observed on the human promyelocytic leukemic cell (HL-60) by NBT reduction test, 125I-cAMP and 125I-cGMP double antibody radioimmune methods, scanning electronic microscopy technique.

RESULTS:

After treating HL-60 cells with Icariin at concentration 0.1 g/L, reduction of NBT and cAMP/cGMP ratio were increased. There were many rugosities and ball-like processes on the cell surface.

CONCLUSION:

Icariin had the effects of induction of differentiation on HL-60 cells, the mechanism might be related to elevating the cAMP/cGMP ratio.

PMID:
10743057
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center