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Microbes Infect. 2000 Feb;2(2):167-76.

Antigenic variation in the persistence and transmission of the ehrlichia Anaplasma marginale.

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Program in Vector-Borne Diseases, Washington State University, Pullman, WA 99164-7040, USA.


Tick-borne transmission of ehrlichial pathogens requires rickettsemic reservoir hosts to maintain a population of infected vectors. Persistence in their respective mammalian hosts appears to be a common feature of the tick-transmitted ehrlichiae. How infection persists in immunocompetent hosts is unknown. In this review, we describe studies on Anaplasma marginale, an ehrlichial pathogen of cattle, that support antigenic variation as a primary mechanism of persistence.

[Indexed for MEDLINE]

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