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Microbes Infect. 2000 Feb;2(2):157-66.

Temperature-regulated expression of bacterial virulence genes.

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School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA.


Virulence gene expression in most bacteria is a highly regulated phenomenon, affected by a variety of parameters including osmolarity, pH, ion concentration, iron levels, growth phase, and population density. Virulence genes are also regulated by temperature, which acts as an 'on-off' switch in a manner distinct from the more general heat-shock response. Here, we review temperature-responsive expression of virulence genes in four diverse pathogens.

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