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Curr Opin Chem Biol. 2000 Apr;4(2):228-34.

Biomimetic modeling of copper oxidase reactivity.

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Department of Chemistry, Stanford University, Stanford, CA 94305, USA.


Bioinspired copper-model-complexes that react with O(2) provide an opportunity to probe biological reactivity at a small-molecule level of detail. Biological structural information combined with appropriate ligand design has proven sufficient to create Cu:O(2) complexes capable of external substrate oxidation. Most notable developments during the review period are the bioinspired catalysts capable of aerobic alcohol-oxidation. The extension of this oxidative reactivity to other important organic transformations beyond the scope of the inspiring system completes a modeling paradigm.

[Indexed for MEDLINE]

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