Send to

Choose Destination
Curr Opin Chem Biol. 2000 Apr;4(2):166-70.

Metal ions in ribozyme folding and catalysis.

Author information

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.


Current research is reshaping basic theories regarding the roles of metal ions in ribozyme function. No longer viewed as strict metalloenzymes, some ribozymes can access alternative catalytic mechanisms depending on the identity and availability of metal ions. Similarly, reaction conditions can allow different folding pathways to predominate, with divalent cations sometimes playing opposing roles.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center