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Horm Metab Res. 2000 Feb;32(2):51-2.

Endomorphin-1, an endogenous mu-opioid receptor-selective agonist, stimulates oxygen consumption in mice.

Author information

1
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.

Abstract

This study was undertaken to investigate the effect of endogenous mu-receptor-selective peptide endomorphin 1, administered intracerebroventricularly, on oxygen consumption in mice. The intracerebroventricular injection of endomorphin 1 (3-30 nmol) significantly increased oxygen consumption in unrestrained mice. The effect of endomorphin 1 (30 nmol) was significantly antagonized by the simultaneous intraperitoneal administration of naloxone (100 nmol). These results suggest that endomorphin 1 stimulates oxygen consumption, and that the mu-opioid receptor influences energy balance in mice.

PMID:
10741684
DOI:
10.1055/s-2007-978587
[Indexed for MEDLINE]

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