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Prog Cell Cycle Res. 2000;4:49-60.

14-3-3 proteins and growth control.

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  • 1Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération Université Paul Sabatier-CNRS, Toulouse, France.


The 14-3-3 proteins constitute a family that is highly conserved in a wide range of organisms, including higher eukaryotes, invertebrates and plants. Variants of 14-3-3 proteins assembled in homo- and heterodimers were found to interact with diverse cellular proteins. Until recently, the biological role of 14-3-3 members was still poorly understood. However, the results of an increasing number of studies on their structure and function are converging to define 14-3-3 proteins as a novel type of adaptor that modulates interactions between components involved in signal transduction pathway and in cell cycle control.

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