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Trends Cell Biol. 2000 Apr;10(4):129-33.

The IKK complex: an integrator of all signals that activate NF-kappaB?

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Unité de Biologie Moléculaire de l'expression Génique, URA 1773 CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.


The NF-kappaB family of transcription factors plays a crucial role in the immune, inflammatory and apoptotic responses. These proteins are normally found in the cytoplasm, retained by interaction with an inhibitory molecule called IkappaB. Activation of the NF-kappaB signalling cascade results in phosphorylation and degradation of IkappaB, allowing nuclear translocation of the NF-kappaB complexes. The recent identification of a high-molecular-weight complex containing two kinases and a regulatory subunit has led to a flurry of new results that shed light on some of the most complex mechanisms contributing to the exquisite regulation of NF-kappaB activity.

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