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Exp Cell Res. 2000 Apr 10;256(1):27-33.

Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis.

Author information

1
MRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester, LE1 9HN, United Kingdom.

Abstract

Caspases play a central role in the execution phase of apoptosis and are responsible for many of the morphological features normally associated with this form of cell death. Caspases can activate one another and consequently can initiate specific caspase cascades. Caspases-8 and -9 appear to be the apical caspases activated in death receptor- and mitochondrial stress-induced apoptosis, respectively. The role of large protein complexes in mediating these pathways is discussed.

PMID:
10739648
DOI:
10.1006/excr.2000.4835
[Indexed for MEDLINE]

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