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Am J Psychiatry. 2000 Apr;157(4):632-4.

High levels of dopamine activity in the basal ganglia of cigarette smokers.

Author information

  • 1Department of Psychiatry, Turku University Central Hospital, Finland. Raimo.K.R.Salokangas@tyks.fi

Abstract

OBJECTIVE:

The authors' goal was to study presynaptic dopamine activity in smoking and nonsmoking human subjects in vivo.

METHOD:

[(18)F]Fluorodopa ([(18)F]DOPA) uptake K(i) values in the basal ganglia of nine smoking and 10 nonsmoking healthy men were measured with positron emission tomography.

RESULTS:

Significantly higher [(18)F]DOPA uptake was observed in both the putamen (average 17.3% higher) and the caudate (average 30.4% higher) of smokers than in those of nonsmokers.

CONCLUSIONS:

Smoking is related to greater dopamine activity in the human basal ganglia. Nicotine-induced dopamine activity may be a relevant mechanism in dependence on cigarette smoking.

PMID:
10739427
DOI:
10.1176/appi.ajp.157.4.632
[PubMed - indexed for MEDLINE]
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