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Protein Sci. 2000 Jan;9(1):201-6.

The pi-helix translates structure into function.

Author information

1
University of Wisconsin La Crosse, Department of Chemistry, 54601, USA. weaver@mail.uwlax.edu

Abstract

A search for the occurrence of the rare pi-helix was performed with Iditis from the Oxford Molecular Group upon the Protein Data Bank. In 8 of the 10 confirmed crystal structures that harbor the pi-helix, its unique conformation has been linked directly to the formation or stabilization of a specific binding site within the protein. In the discussion to follow, the role for each of these eight pi-helices will be addressed in regard to protein function. It is clear upon closer examination that the conformation of the pi-helix has evolved to provide unique structural features within a variety of proteins.

PMID:
10739264
PMCID:
PMC2144447
DOI:
10.1110/ps.9.1.201
[Indexed for MEDLINE]
Free PMC Article
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