Dopamine D3 receptor variant and tardive dyskinesia

Eur Arch Psychiatry Clin Neurosci. 2000;250(1):31-5. doi: 10.1007/pl00007536.

Abstract

In the search for genetic factors contributing to tardive dyskinesia, dopamine receptor genes are considered major candidates. The dopamine D3 receptor is of primary interest as dopamine D3 receptor knock-out mice show locomotor hyperactivation resembling extrapyramidal side-effects of neuroleptic treatment. Furthermore, Steen and colleagues (1997) recently reported an association between tardive dyskinesia and a dopamine D3 receptor gene variant. In the present study we tried to replicate this finding. We investigated 157 patients with schizophrenia or schizoaffective disorder receiving long-term neuroleptic medication who never or persistently displayed tardive dyskinesia. As advanced age is a main risk factor for tardive dyskinesia, we also compared older patients with a long duration of schizophrenia not displaying tardive dyskinesia to younger patients with a shorter duration of the illness displaying tardive dyskinesia. However, we found no evidence that the dopamine D3 receptor gene is likely to confer susceptibility to the development of tardive dyskinesia.

MeSH terms

  • Adult
  • Age Factors
  • Animals
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / pharmacology
  • Antipsychotic Agents / therapeutic use
  • Chromosomes, Human, Pair 3 / genetics
  • Dyskinesia, Drug-Induced / etiology
  • Dyskinesia, Drug-Induced / genetics*
  • Dyskinesia, Drug-Induced / physiopathology
  • Female
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Germany
  • Humans
  • Locomotion / drug effects
  • Male
  • Mice
  • Mice, Knockout
  • Pharmacogenetics
  • Psychotic Disorders / drug therapy
  • Psychotic Disorders / genetics
  • Receptors, Dopamine D2 / genetics*
  • Receptors, Dopamine D2 / physiology
  • Receptors, Dopamine D3
  • Risk Factors
  • Schizophrenia / drug therapy
  • Schizophrenia / genetics

Substances

  • Antipsychotic Agents
  • DRD3 protein, human
  • Drd3 protein, mouse
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3