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Br J Cancer. 2000 Mar;82(5):1000-3.

Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion.

Author information

1
Department of Surgical Oncology, University Hospital Rotterdam Dijkzigt/Daniel den Hoed Cancer Centre, The Netherlands.

Abstract

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-alpha was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP.

PMID:
10737379
PMCID:
PMC2374420
DOI:
10.1054/bjoc.1999.1032
[Indexed for MEDLINE]
Free PMC Article

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