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J Leukoc Biol. 2000 Mar;67(3):267-78.

Insights from mouse models of colitis.

Author information

1
Department of Immunology and Strohm Inflammatory Bowel Disease Center, The Scripps Research Institute, La Jolla, California 92037, USA. boismenu@scripps.edu

Abstract

Emerging studies using mouse models of experimental colitis are defining the nature of the immunological disturbances that initiate inflammation and destruction of the intestine. A better understanding of disease-promoting and -suppressing CD4+ T cells is providing insight into the mechanisms controlling immune responses within the intestinal compartment. Moreover, a role for distinct T cell populations, including intraepithelial gammadelta T cells, in maintaining the physical integrity of the intestine was suggested by recent studies. Cytokine gene-knockout mice and anti-cytokine treatments remain important tools to define the pro- and anti-inflammatory functions of cytokines. These advances are fostering the design and evaluation of new therapeutic approaches that may eventually be applied to treat human inflammatory bowel disease.

PMID:
10733087
DOI:
10.1002/jlb.67.3.267
[Indexed for MEDLINE]

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