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Pharmacotherapy. 2000 Mar;20(3):292-307.

Evaluation and management of drug-induced thrombocytopenia in the acutely ill patient.

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Department of Pharmacy, St. Boniface General Hospital, University of Manitoba, Winnipeg, Canada.


The numerous drugs to which the acutely ill are exposed place these patients at a significant risk of developing drug-induced thrombocytopenia. Such patients tend to have preexisting hemostatic defects that place them at additional risk of complications as a result of the drug-induced thrombocytopenia. The clinical challenge is to provide rapid identification and removal of the offending agent before clinically significant bleeding or, in the case of heparin, thrombosis results. Drug-induced thrombocytopenic disorders can be classified into three mechanisms: bone marrow suppression, immune-mediated destruction, and platelet aggregation. Clinical characteristics, preliminary laboratory findings, and drug history specific to the mechanisms can assist clinicians in rapidly isolating the causative drug.

[Indexed for MEDLINE]

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