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Exp Nephrol. 2000 Mar-Apr;8(2):63-5.

The number of nephrons in the mammalian kidney: environmental influences play a determining role.

Author information

1
Unité de Recherches sur le Développement Normal et Pathologique des Fonctions Epithéliales, Inserm U 319, Université Paris 7-Denis Diderot, Paris, France. Pegorier@Paris7.Jussieu.fr

Abstract

Several lines of evidence, mostly derived from animal studies, indicate that changes in the fetal environment may affect the renal development. Fetal growth retardation is associated with a nephron deficit in both humans and animals. Changes in the supply of vitamin A to the fetus may be responsible for the variations in the number of nephrons in the human kidney. In utero exposure to hyperglycemia or drugs may also cause a nephron deficit.

PMID:
10729743
DOI:
10.1159/000020649
[Indexed for MEDLINE]

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