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Clin Immunol. 2000 Apr;95(1 Pt 2):S3-7.

The thymus and central tolerance.

Author information

1
Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

T cell tolerance to self-components occurs largely in the thymus during early differentiation and leads to death (negative selection) of T cells with overt autoreactivity. In this article we review the evidence that negative selection in mice occurs mainly in the medulla at the level of a population of semimature T cells. The role of Fas and several costimulatory molecules on negative selection and the inhibitory role of certain cytokines are discussed.

PMID:
10729231
DOI:
10.1006/clim.1999.4818
[Indexed for MEDLINE]

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