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Brain Res. 2000 Mar 31;860(1-2):174-7.

Developmental regulation of membrane type-5 matrix metalloproteinase (MT5-MMP) expression in the rat nervous system.

Author information

1
Department of Anatomy, University of Vermont College of Medicine, Given C454, Burlington, VT, USA. djaworsk@zoo.uvm.edu

Abstract

An intricate balance between extracellular matrix (ECM) synthesis and degradation must be maintained during developmental tissue remodeling. Matrix metalloproteinases (MMPs) are the main mediators of ECM degradation. A subset of MMPs, referred to as membrane-type MMPs, contains a transmembrane domain that restricts protease activity at the cell surface. Membrane type-5 MMP is predominantly expressed in the brain. The present report is the first to demonstrate the temporal regulation and spatial distribution of MT5-MMP mRNA during nervous system development.

PMID:
10727639
DOI:
10.1016/s0006-8993(00)02035-7
[Indexed for MEDLINE]

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