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Nat Neurosci. 2000 Apr;3(4):399-403.

Prefrontal modulation of visual processing in humans.

Author information

1
Department of Psychobiology, Faculty of Psychology, Complutense University, Somosaguas 28223, Madrid, Spain.

Abstract

Single neuron, evoked potential and metabolic techniques show that attention influences visual processing in extrastriate cortex. We provide anatomical, electrophysiological and behavioral evidence that prefrontal cortex regulates neuronal activity in extrastriate cortex during visual discrimination. Event-related potentials (ERPs) were recorded during a visual detection task in patients with damage in dorsolateral prefrontal cortex. Prefrontal damage reduced neuronal activity in extrastriate cortex of the lesioned hemisphere. These electrophysiological abnormalities, beginning 125 ms after stimulation and lasting for another 500 ms, were accompanied by behavioral deficits in detection ability in the contralesional hemifield. The results provide evidence for intrahemispheric prefrontal modulation of visual processing.

PMID:
10725931
DOI:
10.1038/73975
[Indexed for MEDLINE]

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