Format

Send to

Choose Destination
Biochim Biophys Acta. 2000 Mar 17;1496(1):142-50.

Understanding the functions of kinesin-II.

Author information

1
Program in Biomedical Sciences, Division of Cellular and Molecular Medicine, Rm. 334, Department of Pharmacology, Howard Hughes Medical Institute, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0683, USA.

Abstract

Species ranging from Chlamydomonas to humans possess the heterotrimeric kinesin-II holoenzyme composed of two different motor subunits and one non-motor accessory subunit. An important function of kinesin-II is that it transports the components needed for the construction and maintenance of cilia and flagella from the site of synthesis in the cell body to the site of growth at the distal tip. Recent work suggests that kinesin-II does not directly interact with these components, but rather via a large protein complex, which has been termed a raft (intraflagellar transport (IFT)). While ciliary transport is the best-established function for kinesin-II, evidence has been reported for possible roles in neuronal transport, melanosome transport, the secretory pathway and during mitosis.

PMID:
10722883
DOI:
10.1016/s0167-4889(00)00015-x
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center