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Fetal Diagn Ther. 2000 Mar-Apr;15(2):93-6.

Efficacy and safety of OK-432 sclerotherapy for giant cystic hygroma in a newborn.

Author information

1
Department of Pediatric Surgery, St George's Hospital, London, UK.

Abstract

BACKGROUND:

OK-432, a lyophilised incubation mixture of group A Streptococcus pyogenes of human origin, was used as a sclerosant for the involution of a giant cervical cystic hygroma in a newborn.

RESULTS:

There were no systemic side effects. Blood tests and double immune diffusion tests showed no systemic infection or generalised inflammatory response, or antibody production. Cellular and cytokine-induced localised inflammatory reaction within the cystic hygroma, was observed on analysis of the intracystic fluid.

CONCLUSIONS:

The leucocytosis induced and activated by OK-432 probably increases the endothelial permeability of the lymphatics. This probably accelerated lymph drainage leading to involution of the cystic hygroma. Intralesional injection of OK-432 was safe and effective therapy for cystic hygroma in this newborn as its inflammatory reaction was localised.

PMID:
10720873
DOI:
10.1159/000020983
[Indexed for MEDLINE]

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