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Int J Exp Pathol. 2000 Feb;81(1):17-30.

Hepatocyte growth factor/scatter factor-induced intracellular signalling.

Author information

1
Laboratory of Cell Biology, Institute of Hepatology, Department of Medicine, Royal Free and University College London Medical School, London, UK.

Abstract

Hepatocyte growth factor (HGF) identical to scatter factor (SF) is a glycoprotein involved in the development of a number of cellular phenotypes, including proliferation, mitogenesis, formation of branching tubules and, in the case of tumour cells, invasion and metastasis. This fascinating cytokine transduces its activities via its receptor encoded by the c-met oncogene, coupled to a number of transducers integrating the HGF/SF signal to the cytosol and the nucleus. The downstream transducers coupled to HGF/MET, most of which participate in overlapping pathways, determine the development of the cell's phenotype, which in most cell types is dual.

PMID:
10718861
PMCID:
PMC2517792
DOI:
10.1046/j.1365-2613.2000.00138.x
[Indexed for MEDLINE]
Free PMC Article

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