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Laryngoscope. 2000 Mar;110(3 Pt 1):429-33.

Hypoxia depresses nitric oxide output in the human nasal airways.

Author information

1
Department of Otolaryngology, St. Michael's Hospital, Ontario, Canada. w.qian@utoronto.ca

Abstract

OBJECTIVES:

The role of oxygen in the nasal air on nasal nitric oxide (NO) output was studied in 13 adult volunteers.

METHODS:

Nasal NO was measured while air containing oxygen (0%-100% in nitrogen) was aspirated through the nasal airway before and after the topical application of xylometazoline.

RESULTS:

The mean nasal NO output of the untreated nose was 507.8 +/- 161.9 nL/min (mean +/- SD) when 21% oxygen was aspirated through the nasal cavities in series and remained unaltered by 100% O2 (P = .79). Below 10% oxygen the reduction in nasal NO output correlated positively and significantly with the decrease in oxygen concentration (r2 = 0.14). NO output was 245.2 +/- 153.4 nL/min at 0% oxygen, a significant decline from 21% oxygen (P < .0001). Nasal vasoconstriction induced by xylometazoline and alterations in the blood oxygen content by a maximal breath-holding or breathing 100% oxygen did not alter nasal NO in hypoxia (P = .41).

CONCLUSIONS:

Nasal NO output is markedly depressed in hypoxia and is oxygen dependent at concentrations of less than 10%. Approximately 50% of nasally generated NO is produced from oxygen in nasal air or regulated by it.

[Indexed for MEDLINE]

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