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Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3224-9.

SAC3 may link nuclear protein export to cell cycle progression.

Author information

1
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

Selective movement of proteins between the nucleus and the cytoplasm is a regulatory mechanism exploited extensively by the eukaryotic cell. We have identified the evolutionarily conserved Sac3 protein, which was implicated previously in the regulation of mitosis [Bauer, A. & Kölling, R. (1996) J. Cell Sci. 109, 1575-1583] as a novel mediator of nuclear protein export. We show that Sac3p is localized to the nuclear pore, where it interacts with nucleoporins. Loss of SAC3 function results in a block in nuclear export of a nuclear export signal-containing reporter protein. Our results also demonstrate that SAC3 interacts genetically with the nuclear protein export factors Crm1p/Xpo1p and Yrb2p. Taken together, these data indicate a link between nuclear protein export and transition through the cell cycle.

PMID:
10716708
PMCID:
PMC16220
DOI:
10.1073/pnas.050432997
[Indexed for MEDLINE]
Free PMC Article
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