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Ann Neurol. 2000 Mar;47(3):365-8.

Association of interleukin-1 gene polymorphisms with Alzheimer's disease.

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  • 1Department of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland.

Abstract

Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's disease through IL-1 overexpression and IL-1-driven neurodegenerative cascades.

PMID:
10716257
PMCID:
PMC3833599
[PubMed - indexed for MEDLINE]
Free PMC Article
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