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Biol Psychiatry. 2000 Mar 15;47(6):557-61.

Hippocampus in Alzheimer's disease: a 3-year follow-up MRI study.

Author information

1
Department of Neurology, Kuopio University Hospital, Kuopio, Finland.

Abstract

BACKGROUND:

Due to the progressive nature of Alzheimer's disease (AD), it has been proposed that serial imaging studies tracking the course of progression might improve the diagnostic accuracy of AD.

METHODS:

Longitudinal changes in hippocampal volumes were evaluated using magnetic resonance imaging (MRI) over a period of 3 years in 27 AD patients and 8 control subjects.

RESULTS:

A statistically nonsignificant trend towards accelerated volume loss in the AD group compared to control subjects was observed. During the study period, the average shrinkage of the hippocampal volume ranged from -2.2% to -5.8% in control subjects, and from -2.3% to -15.6% in AD patients.

CONCLUSIONS:

The observed changes at an individual level were small, and within the accuracy range of the measurements. Therefore, serial MRI of the hippocampus did not offer any advantage over a single MRI to support the diagnosis of AD in this study sample.

PMID:
10715362
DOI:
10.1016/s0006-3223(99)00167-5
[Indexed for MEDLINE]

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