Format

Send to

Choose Destination
See comment in PubMed Commons below
J Mol Biol. 2000 Mar 24;297(2):355-64.

Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions.

Author information

1
Department of Cell and Molecular Biology, Uppsala University, Biomedical Center Box 596, SE-751 24 Uppsala Sweden. Hughes@alpha2.bmc.uu.se

Abstract

The tufA and tufB genes in Salmonella typhimurium co-evolve by recombination and exchange of genetic material. A model is presented which predicts that co-evolution is achieved by gene conversions and chromosomal inversions. Analysis of recombinants reveals that conversion and inversion each occur with similar rates and each depends on RecBCD activity. The model predicts sequence structures for different classes of post-recombination tuf genes. Sequence analysis reveals the presence of each of these structures and classes, with a predicted bias in the absence of mismatch repair. An implication of these data is that co-evolution of gene families can be linked with the generation of chromosomal rearrangements.

PMID:
10715206
DOI:
10.1006/jmbi.2000.3587
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center