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Bioorg Med Chem Lett. 2000 Feb 21;10(4):403-6.

The discovery and synthesis of highly potent, A2a receptor agonists.

Author information

1
Medicinal Sciences, Glaxo Wellcome Medicines Research Centre, Stevenage, Herts, UK. ser0079@glaxowellcome.co.uk

Abstract

A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A2a and A1 receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A2a receptor on the human neutrophil.

PMID:
10714510
[Indexed for MEDLINE]

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