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Curr Opin Immunol. 2000 Apr;12(2):159-65.

To be or not to be a pro-T?

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1
Unité des Cytokines et Développement Lymphoïde, Institut Pasteur, Paris, F-75724, France. disanto@pasteur.fr

Abstract

Recent studies have begun to unravel some of the molecular pathways that appear to control the processes of T cell determination in the earliest thymocyte precursors. In addition, the analyses of mouse mutants with an entirely alymphoid thymus have shed light on the developmental relationship of pro-T cells and thymic dendritic cells, revealing that development of thymocytes and thymic dendritic cells can be dissociated.

PMID:
10712942
[Indexed for MEDLINE]
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