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Curr Opin Immunol. 2000 Apr;12(2):166-72.

Notch signaling in T cell development.

Author information

1
Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA. deftos@u.washington.edu

Abstract

Notch signaling regulates cell fate decisions during development. Recent experiments suggest that Notch signaling is essential for initial commitment to the T cell lineage and may function together with signals from the pre-TCR and the TCR to regulate subsequent steps of T cell development.

PMID:
10712939
DOI:
10.1016/s0952-7915(99)00067-9
[Indexed for MEDLINE]

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