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Curr Opin Immunol. 2000 Apr;12(2):206-9.

Genomic-scale analysis of gene expression in resting and activated T cells.

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Departments of Biochemistry and Molecular Biology, Immunology and Medicine, Howard Hughes Medical Institute, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA.


Recent advances in gene array technology and isolation of lymphocytes now allow comprehensive analysis of gene expression in many different types of T cells. So far only a few sets of results have been published. However it is already clear that these analyses provide accurate measurements of gene expression in T cells. This technology offers the first opportunity to examine global and subtle changes in gene expression in response to specific stimuli.

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